Macroporosity enhances vascularization of electrospun scaffolds

Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds.

Electrospun nanofibrous scaffolds have become widely investigated for tissue engineering applications, owing to their ability to replicate the scale and organization of many fiber-reinforced soft tissues such as the knee meniscus, the annulus fibrosus of the intervertebral disc, tendon, and cartilage. However, due to their small pore size and dense packing of fibers, cellular ingress into elect...

Electrospun Scaffolds for Heart Valve Tissue Engineering

INTRODUCTION Heart valve replacements are required for a number of heart diseases and replacements, as well as for both pediatric and adult populations. It is estimated that 2.5% of the population has valvular heart disease [1], and annually, over 250,000 people worldwide receive heart valve replacements [1]. Tissue engineering (TE) strategies hold the most promise for permanently restoring the...

Multifunctional Ternary Drug-Loaded Electrospun Scaffolds

Electrospun nanostructured scaffolds for tissue engineering applications.

Despite being known for decades (since 1934), electrospinning has emerged recently as a very widespread technology to produce synthetic nanofibrous structures. These structures have morphologies and fiber diameters in a range comparable with those found in the extracellular matrix of human tissues. Therefore, nanofibrous scaffolds are intended to provide improved environments for cell attachmen...

Efficient in vivo vascularization of tissue-engineering scaffolds.

The success of tissue engineering depends on the rapid and efficient formation of a functional blood vasculature. Adult blood vessels comprise endothelial cells and perivascular mural cells that assemble into patent tubules ensheathed by a basement membrane during angiogenesis. Using individual vessel components, we characterized intra-scaffold microvessel self-assembly efficiency in a physiolo...